产品货号：
Z10511
中文名称：
AGAP2抗体
英文名称：
Anti-AGAP2 Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-AGAP2 Antibody |
| 指标别名 | AGAP 2;AGAP2;Centaurin gamma 1;CENTG1;Cnt g1;GGAP2;KIAA0167;PIKE |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse |
| 应用范围 | ELISA,WB,IHC |
| 基因名称 | AGAP2 |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | PIKE antibody was raised against a peptide corresponding to 15 amino acids near the C-terminus of human PIKE.The immunogen is located within the last 50 amino acids of PIKE. |
| 计算分子量 | 125kDa |
| 成分 | PIKE Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | PIKE Antibody is Ion exchange chromatography purified. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Phosphoinositide 3 kinase enhancer (PIKE) is a recently identified nuclear GTPase that interacts with nuclear phosphoinositide 3-kinase (PI3 kinase) to stimulate its lipid kinase activity.PIKE exists in multiple isoforms;a shorter C-terminal isoform (PIKE-A) has also been identified as centaurin gamma 1.The longest isoform (PIKE-L) has been shown to bind to the adaptor protein Homer and thereby link to metabotropic glutamate receptors,leading to activation of PI3 kinase activity and prevention of neuronal apoptosis.Overexpression of PIKE-A enhances Akt activity and promotes cancer cell invasion,whereas decreased expression of PIKE-A via dominant negative expression of PIKE-A or PIKE-A knockdown inhibits these processes.In many human cancers,expression of PIKE-A is enhanced,leading to increased Akt activity and preventing apoptosis. |
| Uniprot ID | Q99490 |
| 基因名全称 | ArfGAP with GTPase domain,ankyrin repeat and PH domain 2 |
| 蛋白名全称 | ArfGAP with GTPase domain,ankyrin repeat and PH domain 2 |
| 推荐稀释比 | PIKE antibody can be used for detection of PIKE by Western blot at 0.5 to 2μg/mL.Antibody can also be used for immunohistochemistry starting at 10μg/mL.Antibody validated:Western Blot in mouse samples and Immunohistochemistry in mouse samples.All other applications and species not yet tested. |
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